cialis
| Product dosage: 10mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 10 | $4.02 | $40.19 (0%) | 🛒 Add to cart |
| 20 | $2.76 | $80.38 $55.26 (31%) | 🛒 Add to cart |
| 30 | $2.34 | $120.56 $70.33 (42%) | 🛒 Add to cart |
| 60 | $1.84 | $241.13 $110.52 (54%) | 🛒 Add to cart |
| 90 | $1.79 | $361.69 $160.75 (56%) | 🛒 Add to cart |
| 120 | $1.59 | $482.26 $190.89 (60%) | 🛒 Add to cart |
| 180 | $1.40 | $723.38 $251.17 (65%) | 🛒 Add to cart |
| 270 | $1.23 | $1085.07 $331.55 (69%) | 🛒 Add to cart |
| 360 | $1.12
Best per pill | $1446.77 $401.88 (72%) | 🛒 Add to cart |
| Product dosage: 2.5mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 30 | $1.51 | $45.21 (0%) | 🛒 Add to cart |
| 60 | $1.34 | $90.42 $80.38 (11%) | 🛒 Add to cart |
| 90 | $1.23 | $135.63 $110.52 (19%) | 🛒 Add to cart |
| 120 | $1.17 | $180.85 $140.66 (22%) | 🛒 Add to cart |
| 180 | $0.89 | $271.27 $160.75 (41%) | 🛒 Add to cart |
| 270 | $0.78 | $406.90 $210.99 (48%) | 🛒 Add to cart |
| 360 | $0.68
Best per pill | $542.54 $246.15 (55%) | 🛒 Add to cart |
| Product dosage: 20mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 10 | $4.52 | $45.21 $45.21 (0%) | 🛒 Add to cart |
| 20 | $3.27 | $90.42 $65.31 (28%) | 🛒 Add to cart |
| 30 | $2.85 | $135.63 $85.40 (37%) | 🛒 Add to cart |
| 60 | $2.51 | $271.27 $150.70 (44%) | 🛒 Add to cart |
| 90 | $2.23 | $406.90 $200.94 (51%) | 🛒 Add to cart |
| 120 | $2.09 | $542.54 $251.17 (54%) | 🛒 Add to cart |
| 180 | $1.67 | $813.81 $301.41 (63%) | 🛒 Add to cart |
| 270 | $1.41 | $1220.71 $381.79 (69%) | 🛒 Add to cart |
| 360 | $1.31
Best per pill | $1627.61 $472.21 (71%) | 🛒 Add to cart |
| Product dosage: 5mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 20 | $2.26 | $45.21 $45.21 (0%) | 🛒 Add to cart |
| 30 | $2.01 | $67.82 $60.28 (11%) | 🛒 Add to cart |
| 60 | $1.51 | $135.63 $90.42 (33%) | 🛒 Add to cart |
| 90 | $1.45 | $203.45 $130.61 (36%) | 🛒 Add to cart |
| 120 | $1.26 | $271.27 $150.70 (44%) | 🛒 Add to cart |
| 180 | $1.12 | $406.90 $200.94 (51%) | 🛒 Add to cart |
| 270 | $0.97 | $610.35 $261.22 (57%) | 🛒 Add to cart |
| 360 | $0.88
Best per pill | $813.81 $316.48 (61%) | 🛒 Add to cart |
Synonyms | |||
Similar products
Cialis, known generically as tadalafil, is a phosphodiesterase type 5 (PDE5) inhibitor prescribed primarily for erectile dysfunction and benign prostatic hyperplasia. It works by relaxing smooth muscles and increasing blood flow to specific areas of the body. Unlike similar medications, Cialis is distinguished by its long duration of action, earning it the nickname “The Weekend Pill.” Its role in modern urology and sexual medicine has been solidified through extensive clinical trials and real-world use, offering a reliable option for men seeking to improve their quality of life.
1. Introduction: What is Cialis? Its Role in Modern Medicine
Cialis (tadalafil) belongs to a class of medications called PDE5 inhibitors, which are central to managing erectile dysfunction (ED) and symptoms of benign prostatic hyperplasia (BPH). Approved by the FDA in 2003, Cialis has become a cornerstone in sexual health due to its prolonged efficacy window of up to 36 hours, allowing for greater spontaneity compared to shorter-acting alternatives like sildenafil (Viagra). Beyond its primary indications, ongoing research explores its potential in pulmonary arterial hypertension and other vascular conditions. For healthcare providers and patients, understanding what Cialis is used for involves recognizing its dual benefits in enhancing erectile function and alleviating urinary symptoms associated with an enlarged prostate.
2. Key Components and Bioavailability of Cialis
The active pharmaceutical ingredient in Cialis is tadalafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5. Tadalafil’s molecular structure contributes to its high selectivity for PDE5 over other phosphodiesterase enzymes, reducing the risk of off-target effects. Available in tablet forms such as immediate-release (2.5 mg, 5 mg, 10 mg, 20 mg) and once-daily formulations (2.5 mg, 5 mg), Cialis is designed for flexibility in dosing. Bioavailability is approximately 36% under fasting conditions, with peak plasma concentrations reached within 2 hours. Absorption is delayed by high-fat meals but not significantly reduced, making it suitable for use with or without food. The inclusion of excipients like crospovidone enhances dissolution, ensuring consistent pharmacokinetics across patient populations.
3. Mechanism of Action of Cialis: Scientific Substantiation
Cialis operates by inhibiting PDE5, an enzyme that breaks down cGMP in the corpus cavernosum of the penis. During sexual stimulation, nitric oxide (NO) is released, activating guanylate cyclase to produce cGMP. This leads to smooth muscle relaxation, vasodilation, and increased blood flow, facilitating an erection. By blocking PDE5, Cialis allows cGMP levels to remain elevated, sustaining the erectile response. In BPH, the same mechanism relaxes smooth muscle in the prostate and bladder neck, improving urinary flow rates and reducing symptoms like hesitancy and frequency. The drug’s long half-life of 17.5 hours is attributed to its slow dissociation from PDE5, providing a durable therapeutic effect that distinguishes it from competitors.
4. Indications for Use: What is Cialis Effective For?
Cialis for Erectile Dysfunction
Cialis is first-line for ED of various etiologies, including vasculogenic, neurogenic, and psychogenic causes. Clinical studies demonstrate significant improvements in International Index of Erectile Function (IIEF) scores, with patients reporting enhanced ability to achieve and maintain erections sufficient for sexual activity.
Cialis for Benign Prostatic Hyperplasia
For men with BPH, Cialis alleviates lower urinary tract symptoms (LUTS) by reducing prostate and bladder outlet obstruction. Trials show statistically significant improvements in IPSS (International Prostate Symptom Score) and peak urinary flow rates, making it a valuable option for those with concomitant ED and BPH.
Cialis for Pulmonary Arterial Hypertension (Off-Label)
Though not FDA-approved for this indication in all regions, tadalafil is used off-label to improve exercise capacity in PAH patients by vasodilating pulmonary arteries. This application is supported by data from randomized controlled trials, highlighting its versatility beyond urological conditions.
5. Instructions for Use: Dosage and Course of Administration
Dosing of Cialis should be individualized based on indication, patient tolerance, and comorbidities. Below is a summary of common regimens:
| Indication | Dosage | Frequency | Administration Notes |
|---|---|---|---|
| Erectile Dysfunction (as needed) | 10 mg | At least 30 minutes before sexual activity | May increase to 20 mg or decrease to 5 mg based on response |
| Erectile Dysfunction (daily) | 2.5 mg or 5 mg | Once daily | Allows for spontaneity; take around the same time each day |
| Benign Prostatic Hyperplasia | 5 mg | Once daily | Assess after 4-6 weeks; may be combined with alpha-blockers cautiously |
| Renal/Hepatic Impairment | 5 mg (max) | As needed or daily | Avoid in severe impairment |
Patients should avoid grapefruit juice and high-fat meals around dosing to prevent delayed absorption. The course of administration is typically long-term, with periodic reassessment by a healthcare provider.
6. Contraindications and Drug Interactions with Cialis
Cialis is contraindicated in patients using nitrates or guanylate cyclase stimulators (e.g., riociguat) due to the risk of severe hypotension. Other contraindications include hypersensitivity to tadalafil, unstable angina, recent stroke or MI, and severe hepatic impairment. Common side effects include headache, dyspepsia, back pain, myalgia, and flushing, which are generally mild and transient. Drug interactions are significant with alpha-blockers (additive hypotension), potent CYP3A4 inhibitors (e.g., ketoconazole, ritonavir—require dose reduction), and antihypertensives. Safety during pregnancy is not applicable as Cialis is not indicated for women.
7. Clinical Studies and Evidence Base for Cialis
The efficacy of Cialis is backed by robust clinical evidence. In a pivotal 12-week, double-blind, placebo-controlled trial involving 400 men with ED, tadalafil 20 mg significantly improved erectile function domain scores versus placebo (p<0.001). For BPH, the REGAIN study showed tadalafil 5 mg daily reduced IPSS by 4.87 points compared to 2.66 for placebo over 12 weeks. Long-term extension studies confirm sustained benefits and safety profiles up to 2 years. Meta-analyses in journals like The Journal of Urology consolidate these findings, establishing Cialis as a well-supported therapeutic option.
8. Comparing Cialis with Similar Products and Choosing a Quality Product
When comparing Cialis to other PDE5 inhibitors, key differentiators include duration of action, flexibility in dosing, and combined indications. Sildenafil (Viagra) acts for 4-6 hours and requires fasting, while vardenafil (Levitra) has a similar duration to sildenafil but may have fewer visual side effects. Tadalafil’s 36-hour window offers unique advantages for spontaneity. For quality assurance, patients should obtain Cialis from licensed pharmacies, verifying packaging for authenticity. Generic tadalafil is bioequivalent and cost-effective, but variability in manufacturing standards necessitates careful sourcing.
9. Frequently Asked Questions (FAQ) about Cialis
What is the recommended course of Cialis to achieve results?
For as-needed use, effects are typically noted within 30-60 minutes. Daily dosing may require 4-5 days to reach steady state for consistent benefits.
Can Cialis be combined with blood pressure medications?
Yes, but under medical supervision due to potential additive hypotensive effects. Dose adjustments may be necessary.
Is Cialis safe for long-term use?
Long-term studies up to 2 years show a favorable safety profile with no new adverse events emerging with extended use.
How does Cialis differ from Viagra?
Cialis has a longer duration (up to 36 hours) versus Viagra’s 4-6 hours, and it is less affected by food intake.
10. Conclusion: Validity of Cialis Use in Clinical Practice
Cialis represents a validated, multipurpose agent in managing erectile dysfunction and benign prostatic hyperplasia, supported by strong clinical data and a well-understood safety profile. Its extended duration of action and dosing flexibility make it a preferred choice for many patients. Healthcare providers should individualize therapy based on patient-specific factors and contraindications to optimize outcomes.
I remember when we first started using tadalafil in our clinic back in the mid-2000s – we had this one patient, Mark, a 58-year-old diabetic with pretty severe ED who’d failed on sildenafil due to unpredictable timing with meals. He was skeptical when I explained the 36-hour window, thought it sounded too good to be true. We started him on 10mg PRN and the transformation was remarkable – not just physically, but psychologically. His wife actually called the clinic to thank us, which doesn’t happen often.
What surprised me was how divided our urology group was initially about the daily dosing option. Some of the older physicians were convinced the continuous PDE5 inhibition would lead to more side effects, while the younger docs pushed for the convenience factor. We had this ongoing debate during our Tuesday case conferences – I recall Dr. Chen arguing that we were “overtreating” with daily tadalafil while I maintained that for patients with regular sexual activity and BPH symptoms, it made perfect sense.
The real learning curve came with the BPH applications. We had a 72-year-old patient, Robert, who presented primarily for urinary symptoms but incidentally mentioned ED. When we started him on daily 5mg tadalafil, his IPSS score dropped from 21 to 11 in 8 weeks, but what we didn’t anticipate was how much his nighttime urination would improve – he went from 4-5 nocturia episodes to 1-2, which dramatically improved his sleep quality and daytime energy. His wife joked that she got her husband back in more ways than one.
We did have our share of failures though – one patient in his early 40s with psychogenic ED actually developed worse performance anxiety on Cialis because the long window made him feel “constantly monitored.” We switched him to a shorter-acting agent with better results. Another case involved a gentleman who took his 20mg dose before a high-fat Thanksgiving dinner and called us panicked when it took nearly 3 hours to work – taught us to be more explicit about food interactions.
The most unexpected finding came from our long-term follow-up data. We’ve been tracking about 200 patients on continuous tadalafil for 3+ years now, and what’s fascinating is how many of them have maintained their initial improvements without dose escalation. One patient, David, now 65, has been on the same 5mg daily dose for 4 years with sustained efficacy for both his ED and mild BPH symptoms. He recently told me during his annual visit, “This isn’t just about sex anymore – it’s about maintaining normal function as I age.”
The longitudinal data has been eye-opening – we’ve seen everything from the expected cardiovascular safety profile holding up to unexpected quality-of-life benefits like improved relationship satisfaction and decreased anxiety about sexual performance. One couple in their late 50s actually credited tadalafil with saving their marriage after 30 years together. While we can’t attribute everything to the medication, the pattern is hard to ignore.
Looking back over 15 years of clinical experience with this medication, what stands out isn’t just the pharmacological profile but how it’s adapted to real people’s lives. The flexibility has proven more valuable than we initially appreciated, and the safety data has held up better than many of us expected. It’s become one of those tools that, when used appropriately, genuinely changes outcomes.