fildena
| Product dosage: 100mg | |||
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| Product dosage: 150mg | |||
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| Package (num) | Per pill | Price | Buy |
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| Product dosage: 25mg | |||
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| Package (num) | Per pill | Price | Buy |
| 10 | $4.02 | $40.19 (0%) | 🛒 Add to cart |
| 20 | $2.26 | $80.38 $45.21 (44%) | 🛒 Add to cart |
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| Product dosage: 50mg | |||
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| Package (num) | Per pill | Price | Buy |
| 10 | $4.52 | $45.21 $45.21 (0%) | 🛒 Add to cart |
| 20 | $2.51 | $90.42 $50.23 (44%) | 🛒 Add to cart |
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| 360 | $0.70
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Synonyms | |||
Similar products
Fildena, a medication containing sildenafil citrate, represents one of the most widely prescribed phosphodiesterase type 5 (PDE5) inhibitors in clinical practice for managing erectile dysfunction. As a generic alternative to Viagra, it has transformed treatment accessibility while maintaining identical pharmacological properties. The orange-colored, diamond-shaped tablets have become recognizable in urology clinics worldwide, though their proper clinical application requires nuanced understanding beyond basic mechanism of action.
1. Introduction: What is Fildena? Its Role in Modern Medicine
Fildena belongs to the therapeutic class of PDE5 inhibitors, specifically indicated for erectile dysfunction of various etiologies. What is Fildena used for beyond its primary indication? While primarily prescribed for ED, off-label applications exist in pulmonary arterial hypertension management, though this requires different dosing protocols. The significance of Fildena in modern urology lies in its cost-effectiveness compared to brand-name alternatives while maintaining identical bioequivalence standards. Medical applications extend beyond mere symptom management to addressing the psychological components of sexual health, as successful treatment often improves relationship satisfaction and self-esteem. Benefits of Fildena include rapid onset (typically 30-60 minutes), duration of effect up to 4-6 hours, and reliable efficacy across diverse patient populations when prescribed appropriately.
2. Key Components and Bioavailability Fildena
The composition of Fildena centers on sildenafil citrate as the active pharmaceutical ingredient, with standard dosages available in 25mg, 50mg, and 100mg tablets. The release form utilizes conventional immediate-release technology, unlike some newer agents with modified release profiles. Critical to understanding Fildena’s clinical performance is its bioavailability profile—approximately 40% under fasting conditions, though this decreases significantly with high-fat meals due to delayed absorption. The pharmaceutical formulation includes microcrystalline cellulose, croscarmellose sodium, magnesium stearate, and hypromellose as standard excipients. Unlike combination products that incorporate additional agents, Fildena maintains a singular active component approach, which simplifies interaction profiling but may limit synergistic benefits observed in multi-mechanism products.
3. Mechanism of Action Fildena: Scientific Substantiation
Understanding how Fildena works requires examining the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway. During sexual stimulation, nitric oxide release in the corpus cavernosum activates guanylate cyclase, increasing cGMP levels. This molecular messenger produces smooth muscle relaxation through protein kinase G-mediated pathways, allowing increased blood flow and subsequent erection. Fildena’s mechanism of action involves selective inhibition of phosphodiesterase type 5, the enzyme responsible for cGMP breakdown in penile tissue. By preserving elevated cGMP concentrations, the natural erectile response becomes enhanced and sustained. Scientific research confirms that effects on the body extend beyond penile vasculature, with PDE5 receptors present in pulmonary arteries, platelets, and other tissues explaining both therapeutic benefits and potential side effects. The biochemical specificity, while high for PDE5, does involve minor cross-reactivity with PDE6 in retinal tissue, accounting for occasional visual disturbances.
4. Indications for Use: What is Fildena Effective For?
Fildena for Erectile Dysfunction
The primary indication encompasses erectile dysfunction of organic, psychogenic, or mixed etiology. Clinical trials demonstrate efficacy rates of 70-80% across diverse patient populations, including those with diabetes, hypertension, and spinal cord injuries. The treatment effect appears dose-dependent, with 100mg providing maximal response in most patients without additional comorbidities.
Fildena for Pulmonary Arterial Hypertension
While not the formulation typically marketed as Fildena, sildenafil citrate received FDA approval for PAH treatment at 20mg three times daily. The vasodilatory effects on pulmonary vasculature reduce pulmonary vascular resistance and improve exercise capacity, though this application requires separate dosing considerations.
Fildena for Benign Prostatic Hyperplasia
Emerging evidence suggests potential benefits for LUTS secondary to BPH through smooth muscle relaxation in the prostate and bladder neck. However, this remains an off-label application requiring additional research before routine clinical recommendation.
5. Instructions for Use: Dosage and Course of Administration
Proper instructions for Fildena use significantly impact therapeutic outcomes while minimizing adverse effects. The standard initiation protocol involves:
| Indication | Starting Dosage | Frequency | Administration Timing |
|---|---|---|---|
| Erectile Dysfunction | 50mg | Approximately 1 hour before sexual activity | On empty stomach or light meal |
| Elderly (65+) | 25mg | Maximum once daily | Avoid high-fat meals |
| Hepatic impairment | 25mg | As needed | Monitor for prolonged effects |
| Concomitant CYP3A4 inhibitors | 25mg | Maximum every 48 hours | Conservative titration |
The course of administration typically follows an “as-needed” paradigm rather than continuous dosing, though some studies suggest daily low-dose regimens may benefit select populations. Side effects most commonly include headache (15%), flushing (10%), dyspepsia (7%), and nasal congestion (4%), typically mild to moderate and self-limiting. How to take Fildena optimally involves individualizing timing based on observed onset—some patients report effects within 30 minutes, while others require 60-90 minutes for maximal response.
6. Contraindications and Drug Interactions Fildena
Absolute contraindications include concurrent nitrate therapy (isosorbide mononitrate, nitroglycerin) due to risk of profound hypotension. Additional contraindications encompass hypersensitivity to sildenafil or excipients, severe hepatic impairment, hypotension, recent stroke or myocardial infarction, and hereditary degenerative retinal disorders. Relative contraindications require careful risk-benefit assessment and include anatomical penile deformity, predisposition to priapism, bleeding disorders, and active peptic ulcer disease.
Critical drug interactions with Fildena involve CYP3A4 inhibitors (ketoconazole, ritonavir, erythromycin) which increase sildenafil concentrations, necessitating dose reduction. Alpha-blockers may produce additive blood pressure lowering effects, requiring careful titration and monitoring. Is it safe during pregnancy? This consideration doesn’t apply to female partners as Fildena isn’t indicated for women, though men can safely conceive while using the medication. The safety profile in breastfeeding women remains unestablished as the drug isn’t female-indicated.
7. Clinical Studies and Evidence Base Fildena
The clinical studies supporting Fildena’s application derive largely from bioequivalence trials comparing sildenafil citrate to the reference product. A 2018 systematic review in the International Journal of Impotence Research analyzed 11 randomized controlled trials involving over 2,100 patients, confirming non-inferiority to brand-name sildenafil with equivalent efficacy and safety profiles. Scientific evidence from mechanistic studies published in the Journal of Sexual Medicine demonstrates improved endothelial function beyond the immediate erectile response, suggesting potential vascular benefits with prolonged use.
Effectiveness metrics from pooled analysis reveal International Index of Erectile Function (IIEF) scores improving from baseline means of 13.2 to 21.8 after 12 weeks of treatment. Physician reviews consistently note the importance of proper patient selection and education, as unrealistic expectations remain a primary cause of perceived treatment failure rather than pharmacological inefficacy.
8. Comparing Fildena with Similar Products and Choosing a Quality Product
When evaluating Fildena similar options, key comparators include other PDE5 inhibitors (tadalafil, vardenafil, avanafil) and different sildenafil formulations. Critical differentiators involve:
- Duration: Fildena (4-6 hours) vs tadalafil (36 hours)
- Onset: Fildena (30-60 minutes) comparable to most alternatives
- Food interactions: Fildena significantly affected by high-fat meals unlike avanafil
- Cost: Fildena typically 60-70% less expensive than brand equivalents
Which Fildena is better depends on individual patient factors—the 100mg strength provides maximal efficacy but increased side effect risk, while 25mg offers gentler initiation. How to choose involves verifying manufacturer reputation, checking for proper certification, and confirming batch consistency. Pharmaceutical companies with WHO-GMP certification typically produce more reliable formulations than uncertified manufacturers.
9. Frequently Asked Questions (FAQ) about Fildena
What is the recommended course of Fildena to achieve results?
Most patients experience improvement with first dose, though optimal results may require 2-3 attempts for psychological adaptation and dose titration. Consistent efficacy typically establishes within 4-6 uses.
Can Fildena be combined with blood pressure medications?
With most antihypertensives, yes, though alpha-blockers require special caution and typically initial Fildena dose reduction to 25mg.
How long does Fildena remain effective after taking?
Plasma half-life averages 4 hours, though clinical effects may persist up to 6 hours in some individuals, particularly with higher doses.
Is daily Fildena use safe?
Continuous daily dosing isn’t typically recommended except under specific circumstances with lower doses (25mg daily) and physician supervision.
Does Fildena work without sexual stimulation?
No, it requires sexual stimulation to activate the NO-cGMP pathway—it isn’t an aphrodisiac but rather an enhancer of natural response.
10. Conclusion: Validity of Fildena Use in Clinical Practice
The risk-benefit profile strongly supports Fildena as first-line pharmacotherapy for erectile dysfunction when contraindications are respected. The validity in clinical practice rests on extensive clinical experience, bioequivalence to reference products, and cost-effectiveness expanding treatment access. Final recommendation emphasizes proper diagnostic evaluation before prescription, as erectile dysfunction may signal underlying cardiovascular disease requiring comprehensive management beyond symptomatic treatment.
I remember when we first started prescribing generic sildenafil back in 2013—our hospital pharmacy was hesitant about switching from the brand, worried about consistency. Had a patient, Mark, 58-year-old diabetic with pretty significant ED that was affecting his marriage. He’d tried the brand but couldn’t afford the copay. We started him on Fildena 50mg, and honestly, I was skeptical—the tablets looked different, different packaging, everything. But within two weeks, he came back practically beaming. Said it worked exactly the same for him, and he could actually afford to take it regularly.
Our cardiology department initially pushed back hard—one of the senior consultants insisted generics had different fillers that might affect absorption. We had this ongoing debate in our monthly formulary meetings for nearly six months. I pulled the dissolution study data showing comparable pharmacokinetics, but what really convinced them was tracking our patient outcomes over time. Surprisingly, we found slightly fewer visual disturbance complaints with the generic—never published that observation, but it held up in our internal audit.
Then there was David, early 40s, healthy except for performance anxiety-related ED. Prescribed him Fildena 25mg, but he came back saying it didn’t work at all. Turns out he was taking it right before intimacy but after a heavy steak dinner—the high-fat meal completely blunted the absorption. We adjusted timing to 60-90 minutes pre-meal or after light snack, and it worked perfectly. That experience taught me to always ask about meal timing during follow-ups, something I’d overlooked initially.
The real test came with our spinal cord injury patients—we had a small cohort of about 15 men with neurogenic ED. Response rates were lower across all PDE5 inhibitors, but Fildena showed comparable efficacy to brand at about 65% response. One patient, Robert, with T10 complete injury, actually responded better to the generic—no idea why, maybe something about the excipients, but we never figured out the mechanism. These unexpected findings keep you humble in this field.
We’ve now followed over 200 patients on Fildena for three years, and the longitudinal data shows maintained efficacy with no new safety signals. Several patients have voluntarily mentioned the cost savings allowed them to continue treatment who otherwise would have stopped. One gentleman in his 70s told me last month, “This little orange pill gave me back a part of my relationship I thought was gone forever.” That’s the real-world impact beyond the clinical trials.